Transplantasyonda koruma solüsyonlarına eklenen P-Coumaric asit ve Ellagic asit etkinliği

OBJECTIVE: In this study, it was aimed to evaluate the protective efficacy of University Wisconsin (UW) and histidine-tryptophan-ketoglutarate (HTK) preservation solutions enriched with P-coumaric acid ellagic acid.
 MATERIAL AND METHOD
 Thirty-six Wistar albino male rats were divided into equal 6ng groups: (Group 1) UW; 2) UW + P-coumaric; 3) Elagic; 4) HTK ;. 5) P-Coumaric; 6) Elagic. After liver perfusion performed, samples taken from tissue fluid at 0, 6 12 hours. At sixth hour, biopsies performed for histopathological electron microscopic examination.
 RESULTS
 groups p-coumaric (group 2 group 5), antioxidant enzyme activities, which higher than control groups, decreased 0th hour difference disappeared 6th 12th hour. Ellagic acid, highest activity in 6, when evaluated terms cytokine activity, are inflammatory parameters, anti-inflammatory cytokines IL4 IL10 found be 3, results 6. similar. 5, although lower group, not significant (P> 0.05). It observed that lowest values ​​in TNF-α, IL1 IL6 but significantly especially ​​(P